| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2012-11-30 |
| タイトル |
|
|
タイトル |
Continuous Infusion of Cyclosporin A in Intravenous Immunoglobulin Resistant Kawasaki Disease Patients |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
coronary lesion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cyclosporine; immunoglobulin resistant |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Kawasaki disease |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 |
Minami, Takaomi
Shiraishi, Hirohiko
Oka, Kensuke
Odaka, Jun
Ishii, Tomoyuki
Takata, Akiko
Sato, Tomoyuki
Kataoka, Koichi
Morimoto, Akira
Momoi, Mariko Y.
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Treatment of intravenous immunoglobulin (IVIG) resistant Kawasaki disease (KD) is challenging.
Continuous infusion of cyclosporin A (CICyA) was employed for 4 patients with IVIG-resistant KD: these patients had remained febrile or had had recurrence of fever within 24 hours after the initial 2g/kg followed by additional 2g/kg IVIG. Response differed between initial doses of CICyA, 1.5 mg/kg/day vs. 3.0 mg/kg/day. The clinical course of the two patients treated with 1.5 mg/kg/day CICyA suggested that the low serum concentration by gradual increase of CICyA did not improve fever or inflammation. The other two patients treated with 3.0 mg/kg/day CICyA became afebrile within 24 hours after initiation of CICyA. They had a subsequently reduced dose of cyclosporin A (CyA) to maintain its appropriate serum concentration (300-500 ng/ml). No coronary artery lesion was detected one month after the onset of KD. The initial dose of 3 mg/kg/day was effective without major side effects and would be a treatment option for IVIG-resistant KD. |
| 書誌情報 |
自治医科大学紀要
en : Jichi Medical University Journal
巻 34,
p. 109-115,
発行日 2012-03
|
| 出版者 |
|
|
出版者 |
自治医科大学 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1881-252X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11819432 |
p109-115 (495.7 kB)
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