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Elevated concentrations of soluble TCTA protein-derived products including an inhibitor of human osteoclastogenesis in peripheral blood of untreated patients with early-onset rheumatoid arthritis
https://jichi-ir.repo.nii.ac.jp/records/1275
https://jichi-ir.repo.nii.ac.jp/records/12755dc9efad-a814-4bcb-a071-081cb3e8bfb5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
自治医科大学紀要 1881-252X(45)P21-28 2023 (377.7 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-06-09 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Elevated concentrations of soluble TCTA protein-derived products including an inhibitor of human osteoclastogenesis in peripheral blood of untreated patients with early-onset rheumatoid arthritis | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | osteoclast | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | rheumatoid arthritis | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | T-cell leukemia translocation-associated gene (TCTA) protein | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 著者 |
Kotake, Shigeru
× Kotake, Shigeru
× Kobashigawa, Tsuyoshi
× Nanke, Yuki
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| 著者別名 | ||||||||||||
| 姓名 | 小竹, 茂 | |||||||||||
| 言語 | ja | |||||||||||
| 著者別名 | ||||||||||||
| 姓名 | 小橋川, 剛 | |||||||||||
| 言語 | ja | |||||||||||
| 著者別名 | ||||||||||||
| 姓名 | 南家, 由紀 | |||||||||||
| 言語 | ja | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | T-cell leukemia translocation-associated gene (TCTA) protein is expressed ubiquitously in normal human tissues, but its function is not completely understood. We have demonstrated that TCTA protein is essential for human osteoclastogenesis induced by NF-kB ligand (RANKL), inhibits the proliferation of both small-cell lung carcinoma and fibroblast-like synoviocytes in rheumatoid arthritis (RA), and may act as a coupling factor in bone metabolism. In the current study, we constructed a high sensitivity sandwich ELISA system and measured the concentration of soluble TCTA protein-derived products (sTDP), which include an inhibitor of human osteoclastogenesis, in the peripheral blood from two groups of untreated patients with early-onset RA and normal volunteers (NV). In the first group, the concentration of sTDP was significantly higher in the 4 RA patients than in the 3 NV (p=0.0339). The level of C-reactive protein(CRP) in serum was not correlated with the concentrations of sTDP in the RA patients. We confirmed these results by analyzing the second group, which was comprised of 22 untreated patients with early-onset RA and 5 NV. In conclusion, sTDP levels were elevated in untreated patients with early-onset RA independent of inflammation. These findings suggest that sTDP play an important role in the pathogenesis of RA by inhibiting both osteoclastogenesis and the proliferation of fibroblast-like synoviocytes. | |||||||||||
| 書誌情報 |
自治医科大学紀要 en : Jichi Medical University Journal 巻 45, p. 21-28, 発行日 2023-03 |
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| 出版者 | ||||||||||||
| 出版者 | 自治医科大学 | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 1881-252X | |||||||||||
