{"created":"2023-06-19T11:23:01.673040+00:00","id":1275,"links":{},"metadata":{"_buckets":{"deposit":"d1386a9d-8e52-4364-8dab-a1cf752ca378"},"_deposit":{"created_by":12,"id":"1275","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"1275"},"status":"published"},"_oai":{"id":"oai:jichi-ir.repo.nii.ac.jp:00001275","sets":["14:1747372335465:46"]},"author_link":[],"control_number":"1275","item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"未治療早期関節リウマチ患者末梢血中にはヒト破骨細胞分化抑制 作用を有するT 細胞性白血病転座関連遺伝子（TCTA）蛋白が上昇 している。","subitem_alternative_title_language":"ja"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"28","bibliographicPageStart":"21","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"自治医科大学紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Jichi Medical University Journal","bibliographic_titleLang":"en"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"T-cell leukemia translocation-associated gene (TCTA) protein is expressed ubiquitously in normal human tissues, but its function is not completely understood. We have demonstrated that TCTA protein is essential for human osteoclastogenesis induced by NF-kB ligand (RANKL), inhibits the proliferation of both small-cell lung carcinoma and fibroblast-like synoviocytes in rheumatoid arthritis (RA), and may act as a coupling factor in bone metabolism. In the current study, we constructed a high sensitivity sandwich ELISA system and measured the concentration of soluble TCTA protein-derived products (sTDP), which include an inhibitor of human osteoclastogenesis, in the peripheral blood from two groups of untreated patients with early-onset RA and normal volunteers (NV). In the first group, the concentration of sTDP was significantly higher in the 4 RA patients than in the 3 NV (p=0.0339). The level of C-reactive protein(CRP) in serum was not correlated with the concentrations of sTDP in the RA patients. We confirmed these results by analyzing the second group, which was comprised of 22 untreated patients with early-onset RA and 5 NV. In conclusion, sTDP levels were elevated in untreated patients with early-onset RA independent of inflammation. These findings suggest that sTDP play an important role in the pathogenesis of RA by inhibiting both osteoclastogenesis and the proliferation of fibroblast-like synoviocytes.","subitem_description_type":"Abstract"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"小竹, 茂","nameLang":"ja"}]},{"names":[{"name":"小橋川, 剛","nameLang":"ja"}]},{"names":[{"name":"南家, 由紀","nameLang":"ja"}]}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"自治医科大学","subitem_publisher_language":"ja"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1881-252X","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kotake, Shigeru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobashigawa, Tsuyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nanke, Yuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-06-09"}],"displaytype":"detail","filename":"自治医科大学紀要 1881-252X(45)P21-28 2023.pdf","filesize":[{"value":"377.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"自治医科大学紀要 1881-252X(45)P21-28 2023","url":"https://jichi-ir.repo.nii.ac.jp/record/1275/files/自治医科大学紀要 1881-252X(45)P21-28 2023.pdf"},"version_id":"e0637a14-4dc3-47e6-91c6-de33f35bea1d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"osteoclast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rheumatoid arthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"T-cell leukemia translocation-associated gene (TCTA) protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"関節リウマチ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"破骨細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞性白血病転座関連遺伝子蛋白","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Elevated concentrations of soluble TCTA protein-derived products including an inhibitor of human osteoclastogenesis in peripheral blood of untreated patients with early-onset rheumatoid arthritis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Elevated concentrations of soluble TCTA protein-derived products including an inhibitor of human osteoclastogenesis in peripheral blood of untreated patients with early-onset rheumatoid arthritis","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["46"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-06-09"},"publish_date":"2023-06-09","publish_status":"0","recid":"1275","relation_version_is_last":true,"title":["Elevated concentrations of soluble TCTA protein-derived products including an inhibitor of human osteoclastogenesis in peripheral blood of untreated patients with early-onset rheumatoid arthritis"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2025-05-28T03:05:01.390651+00:00"}