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Heat-killed Lactobacillus sakei HS-1 mitigates small intestinal pathophysiology on Plasmodium berghei ANKA infected C57BL/6 mice
https://jichi-ir.repo.nii.ac.jp/records/1022
https://jichi-ir.repo.nii.ac.jp/records/10224dda10b6-4177-44be-9707-11bb99f82fec
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
自治医科大学紀要 1881-252X(43)p13-19 2021 (393.7 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2021-05-13 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Heat-killed Lactobacillus sakei HS-1 mitigates small intestinal pathophysiology on Plasmodium berghei ANKA infected C57BL/6 mice | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Heat-killed Lactobacillus sakei HS-1 | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | malaria | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Plasmodium berghei ANKA | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 著者 |
Shimada, Mizuho
× Shimada, Mizuho
× Hayakawa, H. Eri
× Matsuoka, Hiroyuki
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| 著者別名 | ||||||||||||
| 姓名 | 島田, 瑞穂 | |||||||||||
| 言語 | ja | |||||||||||
| 著者別名 | ||||||||||||
| 姓名 | 早川, 枝李 | |||||||||||
| 言語 | ja | |||||||||||
| 著者別名 | ||||||||||||
| 姓名 | 松岡, 裕之 | |||||||||||
| 言語 | ja | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Malaria parasites grow in erythrocytes, while the important symptoms reflecting disease severity are observed in the brain and/or the gastrointestinal (GI) tract in human and murine malaria. Plasmodium berghei ANKA (PbA-) is widely used as an experimental model to cause lethal murine malaria. We previously reported GI pathophysiology with weight loss on PbA-C57BL/6 mice. Accordingly, we hypothesized that mitigation of weight loss might help ameliorate GI pathophysiology on PbA-C57BL/6 mice. This study aimed to investigate whether administration of heat-killed Lactobacillus sakei HS-1 (HK LS HS-1), a newly identified influencing weight gain on healthy domestic animals, mitigates weight loss and/ or GI pathophysiology on PbA-C57BL/6 mice. Six C57BL/6 mice were infected with P. berghei-ANKA strain via infective mosquitoes. Thereafter, half of the mice were randomly assigned to receive HK LS HS-1 from day zero until the day of dissection on day 8. Disease states in mice with and without HK LS HS-1 were compared with respect to weight change, food intake, and GI pathophysiology. This experiment was performed three sets. Overall, the weight (%) was higher in the HK LS HS-1 group than in the control group (p = 0.001), while the food intake (g) was comparable in both the groups. Further, pathological changes of the small intestine did not occur in the HK LS HS-1 group. |
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| 書誌情報 |
自治医科大学紀要 en : Jichi Medical University Journal 巻 43, p. 13-19, 発行日 2021-03 |
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| 出版者 | ||||||||||||
| 出版者 | 自治医科大学 | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 1881-252X | |||||||||||
