{"created":"2023-06-19T11:22:54.729104+00:00","id":1022,"links":{},"metadata":{"_buckets":{"deposit":"26922ac9-a910-477a-a385-13b638e4863a"},"_deposit":{"created_by":12,"id":"1022","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"1022"},"status":"published"},"_oai":{"id":"oai:jichi-ir.repo.nii.ac.jp:00001022","sets":["14:40"]},"author_link":[],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"19","bibliographicPageStart":"13","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"自治医科大学紀要"},{"bibliographic_title":"Jichi Medical University Journal","bibliographic_titleLang":"en"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Malaria parasites grow in erythrocytes, while the important symptoms reflecting disease severity are observed in the brain and/or the gastrointestinal (GI) tract in human and murine malaria. Plasmodium\nberghei ANKA (PbA-) is widely used as an experimental model to cause lethal murine malaria. We previously reported GI pathophysiology with weight loss on PbA-C57BL/6 mice. Accordingly, we hypothesized that mitigation of weight loss might help ameliorate GI pathophysiology on PbA-C57BL/6 mice. This study aimed to investigate whether administration of heat-killed Lactobacillus sakei HS-1 (HK LS HS-1), a newly identified influencing weight gain on healthy domestic animals, mitigates weight loss and/ or GI pathophysiology on PbA-C57BL/6 mice.\nSix C57BL/6 mice were infected with P. berghei-ANKA strain via infective mosquitoes. Thereafter, half of the mice were randomly assigned to receive HK LS HS-1 from day zero until the day of dissection on day 8. Disease states in mice with and without HK LS HS-1 were compared with respect to weight change, food intake, and GI pathophysiology. This experiment was performed three sets.\nOverall, the weight (%) was higher in the HK LS HS-1 group than in the control group (p = 0.001), while the food intake (g) was comparable in both the groups. Further, pathological changes of the small intestine did not occur in the HK LS HS-1 group.","subitem_description_type":"Abstract"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"島田, 瑞穂","nameLang":"ja"}]},{"names":[{"name":"早川, 枝李","nameLang":"ja"}]},{"names":[{"name":"松岡, 裕之","nameLang":"ja"}]}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"自治医科大学"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1881-252X","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimada, Mizuho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hayakawa, H. Eri","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuoka, Hiroyuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-13"}],"displaytype":"detail","filename":"自治医科大学紀要 1881-252X(43)p13-19 2021.pdf","filesize":[{"value":"393.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"自治医科大学紀要 1881-252X(43)p13-19 2021","url":"https://jichi-ir.repo.nii.ac.jp/record/1022/files/自治医科大学紀要 1881-252X(43)p13-19 2021.pdf"},"version_id":"76ab1a26-cba6-42c5-94a1-fbc7b020a897"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Heat-killed Lactobacillus sakei HS-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"malaria","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasmodium berghei ANKA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Heat-killed Lactobacillus sakei HS-1 mitigates small intestinal pathophysiology on Plasmodium berghei ANKA infected C57BL/6 mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Heat-killed Lactobacillus sakei HS-1 mitigates small intestinal pathophysiology on Plasmodium berghei ANKA infected C57BL/6 mice","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-05-13"},"publish_date":"2021-05-13","publish_status":"0","recid":"1022","relation_version_is_last":true,"title":["Heat-killed Lactobacillus sakei HS-1 mitigates small intestinal pathophysiology on Plasmodium berghei ANKA infected C57BL/6 mice"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-08-25T05:58:44.338380+00:00"}