| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2012-10-10 |
| タイトル |
|
|
タイトル |
Changes in serum osteoprotegerin and bone turnover markers in type 2 diabetic hemodialysis patients |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
type 2 diabetes mellitus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
adynamic bone disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bone turnover markers |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
osteoprotegerin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
chronic kidney disease |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 |
Saito, Osamu
Yanaka, Yuki
Saito, Takako
Takeda, Shinichi
Ito, Chiharu
Sasaki, Nobuhiro
Ando, Yasuhiro
Kusano, Eiji
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: It is well known that type 2 diabetic patients easily have bone fracture regardless of normal-high bone mineral density. Otherwise, diabetic hemodialysis patients often have adynamic bone disease, but the precise mechanism underlying this disease remains unclear. Recently, osteoprotegerin (OPG) has been identified as a cytokine that inhibits osteoclast differentiation. The present study was undertaken to evaluate changes in serum OPG and other bone turnover markers in type 2 diabetic hemodialysis patients. We also evaluated the effect of type 2 diabetic change for mineral and bone disorder in hemodialysis patients.
Methods: The subjects were 18 diabetic patients and 34 non-diabetic patients who were receiving hemodialysis. All patients were male. Bone turnover markers, including serum OPG, intact osteocalcin (OC), intact parathyroid hormone (iPTH), tartrate-resistant acid phosphatase (TRAP), and alkaline phosphatase activity (ALP) were measured, and bone volume was determined as the speed of sound (SOS) in the calcaneus by quantitative heel ultrasound.
Results: The SOS value in diabetic patients was significantly smaller than that in non-diabetic patients. The serum OPG level in diabetic patients was significantly higher than that in non-diabetic patients, whereas serum iPTH, OC (a marker of bone formation) and TRAP (a marker of bone resorption) were significantly lower in diabetic patients. There were no significant differences in serum ALP, adjusted calcium, phosphate, and aluminum levels between the two groups.
Conclusion: Type 2 diabetic hemodialysis patients have low bone volume regardless of high levels of OPG and low levels of serum iPTH, OC, and TRAP. These findings suggest type 2 diabetes is a major factor which influence mineral and bone disorder in hemodialysis patients and the effect for bone might be different from the effect under normal kidney function. |
| 書誌情報 |
自治医科大学紀要
en : Jichi Medical University Journal
巻 34,
p. 1-10,
発行日 2012-03
|
| 出版者 |
|
|
出版者 |
自治医科大学 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1881-252X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11819432 |
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