| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2019-08-13 |
| タイトル |
|
|
タイトル |
A New Porcine Model of Autologous Living-donor Liver Transplantation |
|
言語 |
en |
| その他（別言語等）のタイトル |
|
|
その他のタイトル |
ブタを用いた新しい生体肝移植モデル |
|
言語 |
ja |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Living-donor liver transplantation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Autologous transplantation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Porcine model |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Surgical techniques |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 |
Hojo, Nobuyuki
Ishibashi, Toshimitsu
Yasuda, Toshihiko
Sakuma, Yasunaru
Fujiwara, Taketo
Yasuda, Yoshikazu
Nagai, Hideo
|
| 著者別名 |
|
|
|
姓名 |
北條, 宣幸 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
姓名 |
石橋, 敏光 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
姓名 |
安田, 寿彦 |
|
|
言語 |
ja |
| 著者別名 |
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|
姓名 |
佐久間, 康成 |
|
|
言語 |
ja |
| 著者別名 |
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|
姓名 |
藤原, 岳人 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
姓名 |
安田, 是和 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
姓名 |
永井, 秀雄 |
|
|
言語 |
ja |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Living-donor liver transplantation（ LDLT） requires greater surgical experience, higher technical skills, and a more complete understanding of the hepatobiliary system than whole-liver transplantation from brain-dead donors. The usefulness of allograft models of LDLT is limited by problems related to techniques and immunosuppression. Experimental LDLT without rejection requires animal models of autologous transplantation. Porcine models are more anatomically similar to human LDLT than are other experimental models, but successful outcomes of porcine LDLT are very difficult to obtain. We evaluated a new porcine model of autologous LDLT that simulated human surgery in terms of procedural characteristics and technical difficulty. Methods: Fifteen pigs were used, each serving as donor and recipient. The left lobe of the liver was removed and used as the graft. Hepatic and portal venoplasty of the liver graft was performed. The right lobe was excised. The opening of the right medial hepatic vein was enlarged by cutting into the suprahepatic inferior vena cava to facilitate anastomosis. The hepatic vein, portal vein, hepatic artery, and bile duct were reconstructed. Results: Nine of the 15 pigs survived for the target period of 7 or 14 days after surgery. Four of the other 6 pigs died within 4 days after surgery because of technical failures, which might have been avoided by improved surgical skills. Conclusions: The present study revealed that the LDLT model using one pig simultaneously as donor and recipient was technically possible. |
| 書誌情報 |
自治医科大学紀要
en : Jichi Medical University Journal
巻 30,
p. 37-47,
発行日 2008-12
|
| 出版者 |
|
|
出版者 |
自治医科大学 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1881-252X |
自治医科大学紀要1881-252X(30)p37-47 (1.8 MB)
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