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Combined azacitidine and romidepsin enhances cytotoxicity in azacitidine-sensitive but not in azacitidine-resistant multiple myeloma cell lines.
https://jichi-ir.repo.nii.ac.jp/records/350
https://jichi-ir.repo.nii.ac.jp/records/350c34fd577-38ba-4785-b5d0-811a07aec994
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
p13-21 (443.2 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2017-08-14 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Combined azacitidine and romidepsin enhances cytotoxicity in azacitidine-sensitive but not in azacitidine-resistant multiple myeloma cell lines. | |||||||||||
| 言語 | en | |||||||||||
| その他（別言語等）のタイトル | ||||||||||||
| その他のタイトル | アザシチジン感受性および耐性多発性骨髄腫細胞株に対するアザシチジンとロミデプシンの併用効果 | |||||||||||
| 言語 | ja | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | multiple myeloma | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | azacitidine | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | romidepsin | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | DNA demethylating agent | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | histone deacetylase | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 著者 |
Sripayap , Piyanuch
× Sripayap , Piyanuch
× Nagai, Tadashi
× Ozawa, Keiya
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | In hematopoietic tumor cells, aberrant epigenetic alterations of hypermethylation or histone deacetylation are usually observed. In multiple myeloma (MM), histone deacetylase inhibitors (HDIs) have proven anti-tumor activity, whereas the effects of DNA demethylating agents are obscure. In this study, we examined the effect of DNA demethylating agent azacitidine and HDI romidepsin in human MM cell lines RPMI8226 and U266. In RPMI8226 cells, azacitidine restored p16 expression accompanied by disruption of its main target molecules DNA methyltransferases (DNMTs), thereby showing antitumor effect. However, in U266 cells, azacitidine-mediated demethylation was abrogated, thereby losing its anti-myeloma effect. The combination of azacitidine and romidepsin enhanced induction of apoptosis by activation of the caspase pathway in RPMI8226 cells but not in U266 cells. Furthermore, isobologram analyses showed that this combination had an additive inhibitory effect on the growth of RPMI8226 cells, whereas in U266 cells it had a nearly subtractive effect. These results thus suggest that the combination is effective in azacitidine-sensitive but not in azacitidine-resistant MM cells. Taken together, the results support the utility of this combination as a potential therapy for MM; however, this therapy should be considered based on the sensitivity of the particular MM cells to azacitidine. | |||||||||||
| 書誌情報 |
自治医科大学紀要 en : Jichi Medical University Journal 巻 36, p. 13-21, 発行日 2014-03 |
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| 出版者 | ||||||||||||
| 出版者 | 自治医科大学 | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 1881-252X | |||||||||||
