{"_buckets": {"deposit": "d8a1a43e-34f6-47c2-9190-4b529fd285f3"}, "_deposit": {"created_by": 12, "id": "30", "owners": [12], "pid": {"revision_id": 0, "type": "depid", "value": "30"}, "status": "published"}, "_oai": {"id": "oai:jichi-ir.repo.nii.ac.jp:00000030", "sets": ["17"]}, "author_link": [], "control_number": "30", "item_2_alternative_title_1": {"attribute_name": "その他（別言語等）のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "特定の機能性食品摂取による皮膚の抗老化と機能改善作用の検討 抗酸化機能を有するアスタキサンチンおよびビタミンＣ，Ｅ含有飲料長期摂取（20週間）がおよぼす皮膚作用について", "subitem_alternative_title_language": "ja"}]}, "item_2_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-03", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "33", "bibliographicPageStart": "25", "bibliographicVolumeNumber": "35", "bibliographic_titles": [{"bibliographic_title": "自治医科大学紀要"}, {"bibliographic_title": "Jichi Medical University Journal", "bibliographic_titleLang": "en"}]}]}, "item_2_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We studied the long term effects of the oral ingestion of liquid preparations containing Astaxanthin (AX), Vitamin C (VC) and Vitamin E (VE) on anti-aging and functional improvements of human facial skin. The subjects were 66 healthy Japanese female volunteers (mean age 37.26 years) who gave informed consent.\nThe subjects were divided into 3 groups after preliminary skin measurements to minimize differences in their average age and the quantity of the stratum corneum layer water. The first group ingested a liquid preparation containing AX (6 mg) + VC (1000 mg) + VE (10 mg); the second group ingested a liquid preparation containing VC (1000 mg) + VE (10 mg), while the third group (the control group) ingested only the liquid preparation used for the first two groups. Liquid preparations were all normalized to 100 ml, 22 Kcal and each subject took one portion once every day (January-June, 2007) for 20 weeks. The xperiment was carried out using double-blind test methodology. Skin measurements were taken 5 times, at 0, 4, 8, 12 and 20 weeks. The environmental conditions of the skin measurements were as follows; each subject washed her face, with no cosmetics applied, and then seated at rest for 20 minutes in an environmental test room controlled at a temperature of 22±1°C and 50±5% relative humidity. Measurements carried out included determining the water content of the stratum corneum, skin elasticity, wrinkle area  volume, 3 dimensional measurements of wrinkle replicas, and optical observation of the skin through photography. Ocular inspection (skin photographs and 3 dimensional images of replicas) and wrinkle values (wrinkle areas and wrinkle volume rates) revealed significant improvements in the AX+VC+VE group compared to the control group. On the other hand, in the VC+VE group, there was no significant difference compared with the control group. Thus, the results show that the supplementation of AX has significant anti-aging and functional improvements of the skin.", "subitem_description_type": "Abstract"}, {"subitem_description": "我々は，Astaxanthin（以下AX），Vitamin C（以下VC），Vitamin E（以下VE）を含む飲料を，長期間摂取した場合の皮膚の抗老化と機能改善作用について検討した。同意を得た一般健常女性66名（平均年齢37.26歳）を，初回計測値の角層水分量，平均年齢に差が生じないように３群に分け，AX６mg，VC1000mg，VE10mg 含飲料摂取群，VC1000mg，VE10mg含飲料摂取群，飲料基剤のみ摂取するコントロール群とした。飲料はすべて100ml，22Kcal に調整し，20週間（2007.１～６月）毎日１回摂取した。試験は二重盲検法で実施。皮膚計測は，開始前，４，８，12，20週目の計５回，洗顔後化粧品無塗布で恒温恒湿室内20分間座位安静後に行なった。計測項目は，角層水分量，皮膚弾力，皮膚光学写真観察，シワレプリカ３次元計測によるシワ面積・シワ体積である。その結果，目尻の皮膚拡大写真の目視評価およびレプリカ画像解析によるシワ計測値（面積率，体積率）においてAX+VC+VE 群は，コントロール群に比べ有意な改善がみられた。VC+VE群はコントロール群との有意差が認められなかった。これらの試験結果から，AX を含む機能性食品を長期に摂取することによる皮膚の抗老化および機能改善作用が示唆された。", "subitem_description_type": "Abstract"}]}, "item_2_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"names": [{"name": "菅沼, 薫", "nameLang": "ja"}]}, {"names": [{"name": "塩原, みゆき", "nameLang": "ja"}]}, {"names": [{"name": "佐藤, 有希", "nameLang": "ja"}]}, {"names": [{"name": "中村, 千春", "nameLang": "ja"}]}, {"names": [{"name": "前川, 武雄", "nameLang": "ja"}]}, {"names": [{"name": "大槻, マミ太郎", "nameLang": "ja"}]}, {"names": [{"name": "矢澤, 一良", "nameLang": "ja"}]}, {"names": [{"name": "芋川, 玄爾", "nameLang": "ja"}]}]}, "item_2_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "自治医科大学"}]}, "item_2_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1881-252X", "subitem_source_identifier_type": "PISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suganuma, Kaoru", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Shiobara, Miyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sato, Yuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakanuma, Chiharu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Maekawa, Takeo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohtsuki, Mamitaro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yazawa, Kazunaga", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Imokawa, Genji", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2013-06-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "p25-33.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "p25-33", "url": "https://jichi-ir.repo.nii.ac.jp/record/30/files/p25-33.pdf"}, "version_id": "8322aba8-66f2-488d-a9b3-1e083682d586"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "skin aging", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "food supplements", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "antioxidants", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "astaxanthin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "vitamin C", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "皮膚老化", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "機能性食品", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "抗酸化剤", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アスタキサンチン", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ビタミンC", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Anti-aging and functional improvement effects for the skin by functional foods intakes: clinical effects on skin by oral ingestion of preparations containing Astaxanthin and Vitamins C and E", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Anti-aging and functional improvement effects for the skin by functional foods intakes: clinical effects on skin by oral ingestion of preparations containing Astaxanthin and Vitamins C and E", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "12", "path": ["17"], "permalink_uri": "https://jichi-ir.repo.nii.ac.jp/records/30", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2013-06-04"}, "publish_date": "2013-06-04", "publish_status": "0", "recid": "30", "relation": {}, "relation_version_is_last": true, "title": ["Anti-aging and functional improvement effects for the skin by functional foods intakes: clinical effects on skin by oral ingestion of preparations containing Astaxanthin and Vitamins C and E"], "weko_shared_id": -1}