| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2013-06-03 |
| タイトル |
|
|
タイトル |
Serum endothelial injury markers in hemodialysis patients with arteriovenous fistula stenosis |
|
言語 |
en |
| その他（別言語等）のタイトル |
|
|
その他のタイトル |
動静脈シャント狭窄を有する透析患者における血中血管内皮細胞障害マーカー濃度の検討 |
|
言語 |
ja |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
adhesion molecule |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
arteriovenous fistula stenosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
endothelial injury |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hemodialysis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 |
Saito, Osamu
Kotouda, Atushi
Saito, Takako
Sugase, Taro
Akimoto, Tetsu
Ando, Yasuhiro
Muto, Shigeaki
Kusano, Eiji
|
| 著者別名 |
|
|
|
姓名 |
斎藤, 修 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
姓名 |
小藤田, 篤 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
姓名 |
斎藤, 孝子 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
姓名 |
菅生, 太朗 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
姓名 |
秋元, 哲 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
姓名 |
安藤, 康宏 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
姓名 |
武藤, 重明 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
姓名 |
草野, 英二 |
|
|
言語 |
ja |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: In hemodialysis patients, failure of arteriovenous fistula (AVF) is a serious problem. AVF stenosis is dominant cause of vascular access failure. We hypothesized that vascular endothelial damage may be involved in arteriovenous fistula (AVF) stenosis.
Methods: A cross-sectional observational survey was performed in 122 patients receiving maintenance hemodialysis in January-April 2004. Serum levels of adiponectin, adhesion molecules (intercellular adhesion molecule-1; ICAM-1 and vascular cell adhesion molecule-1; VCAM-1), and endothelial injury markers (CD146 and thrombomodulin) were compared between 46 patients with AVF stenosis and 76 patients without AVF stenosis to determine factors associated with AVF stenosis.
Results: The serum adiponectin level was significantly lower in patients with AVF stenosis compared to those without AVF stenosis. Similarly, the serum levels of ICAM-1 and thrombomodulin were significantly lower in patients with AVF stenosis, whereas the serum level of VCAM-1 was significantly higher in patients with AVF stenosis. There were no significant differences in other parameters between the two groups. Logistic regression analysis with the presence or absence of AVF stenosis as the dependent variable showed that administration of an antihypertensive drug, VCAM-1, ICAM-1 and thrombomodulin were significantly associated with the presence of AVF stenosis in hemodialysis patients.
Conclusion: The significant associations of administration of an antihypertensive drug, VCAM-1, ICAM-1 and thrombomodulin with AVF stenosis suggest that endothelial injury may play a critical role in this condition. |
| 書誌情報 |
自治医科大学紀要
en : Jichi Medical University Journal
巻 35,
p. 1-6,
発行日 2013-03
|
| 出版者 |
|
|
出版者 |
自治医科大学 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1881-252X |
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