@article{oai:jichi-ir.repo.nii.ac.jp:00000698, author = {Satoko , Oka and Kazuo , Muroi and Kazuya , Sato and Chizuru , Yamamoto and Masuzu , Ueda and Yoko , Ono and Tomohiro , Matsuyama and Masaki , Toshima and Ken , Ohmine and Katsutoshi , Ozaki and Masaaki , Takatoku and Masaki , Mori and Tadashi , Nagai and Keiya , Ozawa}, journal = {自治医科大学紀要, Jichi Medical University Journal}, month = {Dec}, note = {Based on histological examinations of endoscopic biopsy specimens, gastrointestinal( GI) tract B-cell lymphoma was diagnosed in 18 patients who had GI tract symptoms as their initial presentation. The affected sites were the stomach, small intestine and large intestine in nine, seven, and two patients, respectively. The histological classifications were as follows: thirteen patients had diffuse large B-cell lymphoma, one had mucosa-associated with lymphoid tissue(MALT) lymphoma, one had mantle cell lymphoma, while three patients had other types. The flow cytometric analysis of biopsy specimens showed restricted light chain expression in the specimens from seven out of nine patients. The specimens from three out of the another seven patients showed a high expression of CD19 or CD20, however, no light chain expression was determined in any of the seven patients because of insufficient cell numbers. Abnormal karyotypes were observed in the specimens from two of five patients. The analyses using histological examinations combined with flow cytometry (FCM) for ordinary endoscopy and biopsy specimens were thus found to have a significant value for the diagnosis of GI tract B-cell lymphoma.}, pages = {173--180}, title = {Flow cytometric evaluation of endoscopic biopsy specimens from patients with gastrointestinal tract B-cell lymphoma: a preliminary report}, volume = {30}, year = {2008} }