{"created":"2023-06-19T11:22:43.456414+00:00","id":639,"links":{},"metadata":{"_buckets":{"deposit":"4d7e4d87-7f71-4b99-af0f-22f0f7f5aebd"},"_deposit":{"created_by":12,"id":"639","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"639"},"status":"published"},"_oai":{"id":"oai:jichi-ir.repo.nii.ac.jp:00000639","sets":["14:31"]},"author_link":[],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"自治医科大学紀要"},{"bibliographic_title":"Jichi Medical University Journal","bibliographic_titleLang":"en"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"卵白アルブミン（OVA）溶液を抗原とし，マウスの眼球結膜，鼻粘膜に塗布して抗OVA IgE 抗体の誘導に成功した。つぎにマウスを２群に分け，１群には旋毛虫Trichinella spiralis Polish strain （Tsp）を感染させ，残りの１群には感染させなかった。Tsp 感染５週後全マウスを殺処分し，OVA 特異的IgE をELISA（enzyme linkedimmunosorbent assay）およびPCA（passive cutaneous anaphylaxis 受身皮膚アナフィラキシー）反応にて評価した。ELISA によるとOVA 特異的IgE はTsp 感染によって増加あるいは減少することはなかった。一方PCA 反応ではTsp 感染群血清においてOVA による皮膚反応の強い抑制がみられた。Tsp の感染を受けたマウスの肥満細胞が非特異的IgE によって占領されたため，OVA 特異的IgE のFc レセプターへの結合，あるいは架橋反応が阻害されたためと考察した。総IgE はOVA 塗布のみのコントロール群では0.25μg/ml 以下だったが，Tsp 感染群では2.9～11.7μg/ml と高値を示した。このうちTsp 特異的IgE はごくわずかであると考えられた。以上より，OVA 特異的IgE が存在していても，寄生虫感染により非特異的IgE を増加させることで，競合的にⅠ型アレルギー反応を抑制できる可能性が示された。","subitem_description_type":"Abstract"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"Hiroyuki, Matsuoka","nameLang":"en"}]},{"names":[{"name":"Kazuhiro, Ohara","nameLang":"en"}]},{"names":[{"name":"Masaki, Tanabe","nameLang":"en"}]}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"自治医科大学"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1881-252X","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松岡, 裕之","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"大原, 一倫","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"田辺, 正樹","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-08"}],"displaytype":"detail","filename":"自治医科大学紀要1881-252X(31)p1-8.pdf","filesize":[{"value":"791.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"自治医科大学紀要1881-252X(31)p1-8","url":"https://jichi-ir.repo.nii.ac.jp/record/639/files/自治医科大学紀要1881-252X(31)p1-8.pdf"},"version_id":"f137afa8-35e9-43fd-8f8a-5c1767c5d9f5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ELISA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IgE","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"アレルギー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"受身皮膚アナフィラキシー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"寄生虫感染","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"寄生虫感染により誘導された非特異的IgE による Ⅰ型アレルギー反応の抑制","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"寄生虫感染により誘導された非特異的IgE による Ⅰ型アレルギー反応の抑制","subitem_title_language":"ja"},{"subitem_title":"Inhibition of type 1 allergic reaction using non-specific immunoglobulin E induced by parasite infection","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["31"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-08"},"publish_date":"2019-07-08","publish_status":"0","recid":"639","relation_version_is_last":true,"title":["寄生虫感染により誘導された非特異的IgE による Ⅰ型アレルギー反応の抑制"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-08-25T06:06:44.340638+00:00"}