{"created":"2023-06-19T11:22:42.980875+00:00","id":613,"links":{},"metadata":{"_buckets":{"deposit":"bdbd8fe5-394e-45d4-9cc1-db6c1e5ca31a"},"_deposit":{"created_by":12,"id":"613","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"613"},"status":"published"},"_oai":{"id":"oai:jichi-ir.repo.nii.ac.jp:00000613","sets":["14:28"]},"author_link":[],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"153","bibliographicPageStart":"147","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"自治医科大学紀要"},{"bibliographic_title":"Jichi Medical University Journal","bibliographic_titleLang":"en"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"メトロニダゾールに対する副反応のためにチニダゾールで治療した後天性免疫不全症候群に併発したアメーバ性大腸炎を経験した。症例は42歳，男性。入院３ヶ月前から下痢が持続し他院入院。下部内視鏡検査でアメーバ性大腸炎と診断され，メトロニダゾールの内服が開始された。投与３日目に四肢と前胸部に皮疹が出現したため内服を中止した。その後，食欲低下と急激な体重減少，会話時の息切れ，動悸が出現し当院を受診。ヒト免疫不全ウイルス-RNA 量が2.0×106コピー/ml，末梢血CD4陽性リンパ球数が63 /μlであったことから後天性免疫不全症候群に併発したニューモシスチス肺炎による低酸素血症の診断で入院となった。なお，同性愛については再三否定。sulfamethoxazole-trimetoprim合剤とプレドニゾロンによる治療中，第11病日より39℃台の発熱と頻回の水様性下痢が見られた。第15病日に下部内視鏡検査を施行したところ，大腸粘膜全体の糜爛形成と生検組織内にアメーバ虫体を認め，アメーバ性大腸炎の再発と診断。第17病日よりメトロニダゾールの投与開始し解熱傾向となった。しかし，第22病日に再度39℃台の発熱が出現したためメトロニダゾールを中止し，チニダゾールの内服に変更した。その後は，発熱なく下痢の回数も減少し便潜血も陰性化した。外来でHighly Active Anti-Retroviral Therapyを開始する方針となり，第43病日に退院した。メトロニダゾール，チニダゾールともにアメーバ性大腸炎の治療薬としては，保険適応外の使用であり，早期の適応症追加が望まれる。","subitem_description_type":"Abstract"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"Tamami, WATANABE","nameLang":"en"}]},{"names":[{"name":"Hitoshi, SUGAWARA","nameLang":"en"}]},{"names":[{"name":"Hiroshi, MATSUBAYASHI","nameLang":"en"}]},{"names":[{"name":"Akira, ISHII","nameLang":"en"}]},{"names":[{"name":"Atsushi, AOKI","nameLang":"en"}]},{"names":[{"name":"Shinya, USHIMARU,","nameLang":"en"}]},{"names":[{"name":"Mitsuhiro, NOKUBI","nameLang":"en"}]},{"names":[{"name":"Junji, NISHIDA","nameLang":"en"}]},{"names":[{"name":"Yukio, YOSHIDA","nameLang":"en"}]},{"names":[{"name":"Masanobu, KAWAKAMI","nameLang":"en"}]}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"自治医科大学"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1881-252X","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡辺, 珠美","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"菅原, 斉","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"松林, 洋志","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"石井, 彰","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"青木, 厚","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"牛丸, 信也","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"野首, 光弘","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"西田, 淳二","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"吉田, 行雄","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"川上, 正舒","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-01"}],"displaytype":"detail","filename":"自治医科大学紀要1881-252X(33)p147-153.pdf","filesize":[{"value":"1.3 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colitis,","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"AIDS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tinidazole","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metronidazole","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"メトロニダゾールに対する副反応のために チニダゾールで治療し得た後天性免疫不全症候群に 併発したアメーバ性大腸炎の１例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"メトロニダゾールに対する副反応のために チニダゾールで治療し得た後天性免疫不全症候群に 併発したアメーバ性大腸炎の１例","subitem_title_language":"ja"},{"subitem_title":"A case of amoebic colitis associated with AIDS successfully treated with tinidazole following an allergic reaction to metronidazole","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["28"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-01"},"publish_date":"2019-07-01","publish_status":"0","recid":"613","relation_version_is_last":true,"title":["メトロニダゾールに対する副反応のために チニダゾールで治療し得た後天性免疫不全症候群に 併発したアメーバ性大腸炎の１例"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-08-25T06:06:11.507954+00:00"}