@article{oai:jichi-ir.repo.nii.ac.jp:00000033,
 author = {Kawai, Atsuko and Nishino, Satoshi and Kurita, Masatake and Mitomo, Masaaki and Numata, Yukio and Sato, Tadahiro and Nishimatsu, Yoshiko and Nakamura, Masakazu and Hamajima, Nobuyuki and Nakamura, Yoshikazu},
 journal = {自治医科大学紀要, Jichi Medical University Journal},
 month = {Mar},
 note = {Background：Dopamine D2 receptor (DRD2) TaqIA polymorphism was reported to be associated with the smoking habits. This study aimed to investigate the associations between DRD2 TaqIA polymorphism and smoking habits among Japanese males with schizophrenia. It is well-known that the smoking rate among them is higher and they are nicotine dependent.
Methods：Subjects were 105 male inpatients or outpatients with schizophrenia (mean age ± standard deviation, 44.8 ± 12.3 years) treated at Koutokukai Sato Hospital between 2001 and 2002, who gave informed consent for this study. DRD2 TaqIA (A1/A2) was genotyped with a PCT-CTPP (polymerase chain reaction with confronting two-pair primers) method. The associations was examined with smoking habits, the age at smoking initiation, number of cigarettes per day, nicotine dependence assessed with the Tobacco Dependence Screener (TDS) and the Fagerström Tolerance Questionnaire (FTQ), and the longest duration of smoking cessation.
Results：Among 81 current smokers, number of cigarettes per day was significantly associated with the genotype (p=0.022); mean ± standard deviation was 16.1 ± 5.6 for A1A1, 22.7 ± 9.3 for A1A2, and 26.8 ± 12.4 for A2A2. The age-adjusted odds ratio was 0.09 (95% confidence interval, 0.01-0.86) for A1A1 relative to A2A2. No significant associations were observed between DRD2 TaqIA polymorphism and the other smoking habits.
Conclusion：This preliminary study suggested that cigarette consumption was significantly reduced in schizophrenic male patients with DRD2 TaqIA A1A1 genotype in Japan. However, our finding needs further research because of its small sample size., 2001年から2002年に公徳会佐藤病院で入院あるいは外来治療中の男性統合失調症患者で本研究の同意を得た105人（平均年齢±標準偏差，44.8±12.3歳）を対象に，ドーパミンD2受容体（DRD2）TaqIA 遺伝子多型と喫煙習慣との関連を検討した。81人の現喫煙者において，DRD2 TaqIA の遺伝子多型A1A1 型はA2A2型に比べ１日喫煙本数が有意に少なかった（ｐ＝0.022；平均±標準偏差はA1A1型で16.1±5.6，A1A2型で22.7±9.3，A2A2型で26.8±12.4）。A2A2型に対するA1A1型の年齢調整オッズ比は0.09（95% 信頼区間，0.01-0.86）であった。DRD2 TaqIA 遺伝子多型と喫煙開始年齢，ニコチン依存度テスト（TDS・FTQ），最長禁煙期間の間では有意な関係は認められなかった。ただし，本研究は対象数が少なく，さらなる調査が必要である。},
 pages = {49--55},
 title = {DRD2 Polymorphism and Smoking Habits in Japanese Males with Schizophrenia},
 volume = {35},
 year = {2013}
}